a river flowing SE from the Allegheny Mountains in West Virginia, along the boundary between Maryland and Virginia to the Chesapeake Bay. 287 mi. (460 km) long.
2.
a city in central Maryland, near Washington, D.C. 40,402.
Po·to·mac River (pə-tō'mək) A river of the east-central United States rising in northeast West Virginia and flowing about 459 km (285 mi) along the Virginia-Maryland border to Chesapeake Bay. It is navigable for large ships to Washington, D.C.