protamine

protamine

[proh-tuh-meen, pro-tam-in]
noun Biochemistry.
any of a group of arginine-rich, strongly basic proteins that are not coagulated by heat, occurring primarily in the sperm of fish.

Origin:
1870–75; prot- + amine

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protamine (ˈprəʊtəˌmiːn)
 
n
any of a group of basic simple proteins that occur, in association with nucleic acids, in the sperm of some fish
 
[C19: from German: see proto-, amine]

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American Heritage
Medical Dictionary

protamine pro·ta·mine (prō'tə-mēn', -mĭn) or pro·ta·min (-mĭn)
n.
Any of a group of simple proteins found in fish sperm that are strongly basic, are soluble in water, are not coagulated by heat, and yield chiefly arginine upon hydrolysis. In purified form, they are used in a long-acting formulation of insulin and to neutralize the anticoagulant effects of heparin.

The American Heritage® Stedman's Medical Dictionary
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Encyclopedia Britannica
Encyclopedia

protamine

simple alkaline protein usually occurring in combination with a nucleic acid as a nucleoprotein. In the 1870s Johann Friedrich Miescher discovered a protamine, salmine, in the sperm of salmon. Other typical protamines include sturine, from sturgeon, and clupeine, from herring sperm. The drug protamine sulfate, prepared from the sperm of various fishes, is used as an antidote to overdoses of the anticoagulant heparin.

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Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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