pyopneumoperitonitis py·o·pneu·mo·per·i·to·ni·tis (pī'ō-n&oomacr;'mō-pěr'ĭ-tn-ī'tĭs, -ny&oomacr;'-) n. Suppurative peritonitis accompanied by gas produced by gas-forming microorganisms or introduced from a ruptured bowel.