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late 14c., "woman with the power of soothsaying," from Old French phitonise (13c.), from Late Latin pythonissa, used in Vulgate of the Witch of Endor (I Sam. xxviii:7), and often treated as her proper name, literally fem. of pytho "familiar spirit;" which ultimately is connected with the title of the prophetess of the Delphic Oracle, Greek pythia hiereia, from Pythios, an epithet of Apollo, from Pytho, older name of the region of Delphi (see python).