Diagnosed with refractory acute myeloid leukemia at age 7, Sam was very brave but also very sick.
On the 23rd of November, still more unequivocal symptoms of a refractory spirit appeared in the Irish parliament.
She tugs and pulls, and thumps the refractory thing on the floor.
He rode back a short distance, and used all the arts of his horsemanship to reduce his refractory steed to obedience.
James was a refractory and disobedient child from the very cradle.
My arms ache; the mob of slaves get more and more dirty and refractory.
She evidently dreaded a meeting with her refractory teacher.
He remonstrated with the Judan fathers, he even cursed them, and finally caused the refractory to be punished.
The porters were not always easy to manage, and on some occasions were refractory.
The most refractory male is always forced to lower his standard before the conquering arms of woman.
"stubborn, obstinate, perverse," 1610s (earlier refractorious, 1550s, refractary, c.1600), from Latin refractarius "obstinate, stubborn," from past participle stem of refringere (see refraction). Related: Refractorily; refractoriness.
refractory re·frac·to·ry (rĭ-frāk'tə-rē)
Resistant to treatment, as a disease.
Unresponsive to stimuli, as a muscle or nerve fiber.