Diagnosed with refractory acute myeloid leukemia at age 7, Sam was very brave but also very sick.
"stubborn, obstinate, perverse," 1610s (earlier refractorious, 1550s, refractary, c.1600), from Latin refractarius "obstinate, stubborn," from past participle stem of refringere (see refraction). Related: Refractorily; refractoriness.
refractory re·frac·to·ry (rĭ-frāk'tə-rē)
Resistant to treatment, as a disease.
Unresponsive to stimuli, as a muscle or nerve fiber.