1520s, originally a sailors' word, from Middle Dutch splissen "to splice," ultimately from PIE *(s)plei- "to split, splice" (see flint). The Dutch word was borrowed in French as épisser. Used of motion picture film from 1912; of DNA from 1975. Related: Spliced; splicing.
To join together genes or gene fragments or insert them into a cell or other structure, such as a virus, by means of enzymes. In genetic engineering, scientists splice together genetic material to produce new genes or to alter a genetic structure. In messenger RNA, the introns are removed, and exons are spliced together to yield the final messenger RNA that is translated. See also exon, intron.
[1843+; orig US jocular formation from splendid]