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Proceed to its logical or natural conclusion, as in The doctor said the cold would probably run its course within a week. This idiom employs course in the sense of “an onward movement in a particular path.” [ Second half of 1500s ]
The American Heritage® Idioms Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Word Value for run

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Quotes with run its course