1640, from
self (q.v.). Said in Hacket's life of Archbishop Williams (1693) to have been coined by Presbyterians. In the 17c., synonyms included
self-seeking (1628),
self-ended and
self-ful."Let us understand what our own selfish genes are up to, because we may then at least have the chance to upset their designs." [Richard Dawkins, "The Selfish Gene," 1976]