| a generalized allergic reaction to a foreign serum or drug, characterized by fever, skin rash, enlarged lymph nodes, and painful joints. |

| serum sickness n. A hypersensitive reaction to the administration of a foreign serum, characterized by fever, swelling, skin rash, and enlargement of the lymph nodes. |
serum sickness n.
A hypersensitive reaction to the administration of a foreign serum, marked by fever, swelling, skin rash, and lymph node enlargement. Also called serum disease, serum reaction.
serum sickness
an allergic reaction to animal serum or antiserum injected into an individual's blood to provide immunity against such illnesses as tetanus, botulism, and snake-venom poisoning. Symptoms include skin eruption, itching, swelling of the face and extremities, fever, joint pain and sometimes swelling, abdominal pain, nausea, and vomiting; severe cases may also show neurological symptoms.
Learn more about serum sickness with a free trial on Britannica.com.