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A difficult and confused situation; an uproar; melee; mess, rhubarb: It became clear that the whole shlamozzle, introns and exons, are transcribed into RNA (1899+)
To depart; powder, scram (1903+)
[ultimately probably fr Yiddish shlim mazel, ''rotten luck,'' hence ''a difficulty or misfortune,'' and related to shlemazel]