Perhaps the most significant structural flaw in the current system, however, is that the fox is guarding the henhouse.
The most quoted speech at CPAC this year was Mitt Romney's, but my vote for the most significant goes to Grover Norquist's.
However, there are significant differences to Hirst and Choe that help collapse the comparison.
1570s, "having a meaning," from Latin significantem (nominative significans, present participle of significare "make known, indicate" (see signify). Earlier in the same sense was significative (c.1400). Often "having a special or secret meaning," hence "important" (1761). Related: Significantly. Significant figure is from 1680s. Significant other (n.) attested by 1961, in psychology, "the most influential other person in the patient's world."