Perhaps the most significant structural flaw in the current system, however, is that the fox is guarding the henhouse.
The most quoted speech at CPAC this year was Mitt Romney's, but my vote for the most significant goes to Grover Norquist's.
However, there are significant differences to Hirst and Choe that help collapse the comparison.
As Hill has suffered from overexposure, other significant women of Everest have gone unnoticed, especially among the sherpanis.
The return of John Lurie is significant on several levels, quite apart from the specific strengths of his music and his art.
I exposed to him the conclusion we in Brussels had arrived at, and pointed out the significant series of failures.
Its most significant details were of a sordid kind, familiar to poverty.
The secret lies chiefly in passing quickly from one significant point to another.
"You do not know but it may be a friend," was his significant answer.
The manner in which the losses thus caused were repaired is significant and instructive.
1570s, "having a meaning," from Latin significantem (nominative significans, present participle of significare "make known, indicate" (see signify). Earlier in the same sense was significative (c.1400). Often "having a special or secret meaning," hence "important" (1761). Related: Significantly. Significant figure is from 1680s. Significant other (n.) attested by 1961, in psychology, "the most influential other person in the patient's world."