marijuana from seedless female hemp plants that contain very high levels of THC.

1975–80; < American Spanish, equivalent to Spanish sin without (< Latin sine) + semilla seed, apparently continuation of Old Spanish dialect semilia, by dissimilation from Late Latin sēminia, neuter plural (taken as feminine singular) of sēminium, derivative of Latin sēmen seed, semen Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
sinsemilla (ˌsɪnsəˈmiːljə)
1.  a type of marijuana with a very high narcotic content
2.  the plant from which it is obtained
[C20: from American Spanish, literally: without seed]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin & History

potent strain of marijuana, 1975, from Mex.Sp., lit. "without seed."
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
By growing high-potency sinsemilla, domestic marijuana growers provide a product that easily competes with other suppliers.
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