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"muddy place," Old English sloh "soft, muddy ground," of uncertain origin. Cf. Middle Low German sloch "muddy place," Middle High German sluoche "ditch." Figurative use (e.g. of moral sunkenness or Bunyan's "Slough of Despond," 1678) attested from mid-13c.
"cast-off skin" (of a snake or other animal), early 14c., slughe, slouh, probably related to Old Saxon sluk "skin of a snake," Middle High German sluch "snakeskin, wineskin," Middle Low German slu "husk, peel, skin," German Schlauch "wineskin;" from Proto-Germanic *sluk-, of uncertain origin, perhaps from PIE root *sleug- "to glide."
"to cast off" (as the skin of a snake or other animal), 1720, originally of diseased tissue, from Middle English noun slough "shed skin of a snake" (see slough (n.)). Related: Sloughed; sloughing.
A layer or mass of dead tissue separated from surrounding living tissue, as in a wound, a sore, or an inflammation. v. sloughed, slough·ing, sloughs
To separate from surrounding living tissue. Used of dead tissue.
A slot machine; one-arm bandit: The slots are going day and night (1950+)