[south-paw] Informal.
a person who is left-handed.
a player who throws with the left hand, especially a pitcher.
Boxing. a boxer who leads with the right hand and stands with the right foot forward, using the left hand for the most powerful blows.

1880–85, Americanism; south + paw1 Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
southpaw (ˈsaʊθˌpɔː)
1.  a boxer who leads with his right hand and off his right foot as opposed to the orthodox style of leading with the left
2.  any left-handed person
3.  of or relating to a southpaw
[C20: from paw (in the sense: hand): originally a term applied to a left-handed baseball player: perhaps so called because baseball pitchers traditionally face west, so that a left-handed pitcher would throw with the hand on the south side of his body]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

"lefthander," 1885, originally baseball slang, of pitchers, often said to have been coined by Finley Peter Dunne ("Mr. Dooley"), Chicago sports journalist and humorist, in the days when baseball diamonds were regularly oriented with home plate to the west. But south paw "a person's left hand" is attested
from 1848 in the slang of pugilism.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
Many have credited the southpaw's success to his new cutter, a pitch that's grown in popularity in the major leagues as of late.
The southpaw stance, conversely, is vulnerable to a straight right hand.
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