1 [spey]
verb (used with object) Veterinary Medicine.
to remove the ovaries of (an animal).

1375–1425; late Middle English spayen < Anglo-French espeïer to cut with a sword (Old French espeer), derivative of espee sword; see épée

unspayed, adjective

spade, spayed. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
spay (speɪ)
(tr) to remove the ovaries, and usually the uterus, from (a female animal)
[C15: from Old French espeer to cut with the sword, from espee sword, from Latin spatha]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

c.1410, "stab with a sword, kill," also "remove the ovaries of," from Anglo-Fr. espeier "cut with a sword," from M.Fr. espeer, from O.Fr. espee "sword" (Fr. épée), from L. spatha "broad, flat weapon or tool," from Gk. spathe "broad blade" (see spade (1)).
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

spay (spā)
v. spayed, spay·ing, spays
To surgically remove the ovaries of an animal.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Example sentences
She is spayed, totally housebroken and was taught to sleep in a crate as well
  as nap there when her owner leaves.
Dogs don't have to be spayed or neutered, but if they aren't, they cannot be
  allowed to play with other dogs.
Also, dogs that are not spayed and neutered often exhibit aggressive behavior.
Dixie is spayed, chipped and up to ate on her shots.
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