spo·ro·tri·cho·sis (spôr'ə-trĭ-kō'sĭs, spōr'-) n. A chronic infectious disease of domestic mammals and humans, characterized by nodules or ulcers in the lymph nodes and skin and caused by a saprophytic or parasitic fungus of the genus Sporothrix, especially S. schenckii, commonly found in soil and wood.