Main Entry: sub·stan·tia ni·gra Pronunciation: s&b-"stan-chE-&-'nI-gr&, -'nig-r& Function: noun Inflected Form: pluralsub·stan·ti·ae ni·grae/-chE-"E-'nI-(")grE, -'nig-(")rE/ : a layer of deeply pigmented gray matter situated in the midbrain and containing thecell bodies of a tract of dopamine-producing nerve cells whose secretion tends to be deficient in Parkinson's disease
substantia nigra substantia ni·gra (nī'grə, nĭg'rə) n. A layer of large pigmented nerve cells in the mesencephalon that produce dopamine and whose destruction is associated with Parkinson's disease. Also called nigra.