thalassemia

thalassemia

[thal-uh-see-mee-uh]
noun Pathology.
a hereditary form of anemia, occurring chiefly in people of Mediterranean origin, marked by the abnormal synthesis of hemoglobin and a consequent shortened life span of red blood cells.
Also called Cooley's anemia.


Origin:
1932; < Greek thálass(a) sea (alluding to the Mediterranean Sea; the anemia was first reported among children in Mediterranean countries) + -emia

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thalassaemia or (US) thalassemia (ˌθæləˈsiːmɪə)
 
n
Also called: Cooley's anaemia a hereditary disease, common in many parts of the world, resulting from defects in the synthesis of the red blood pigment haemoglobin
 
[New Latin, from Greek thalassa sea + -aemia, from it being esp prevalent round the eastern Mediterranean Sea]
 
thalassemia or (US) thalassemia (ˌθæləˈsiːmɪə, ˈkuːlɪz)
 
n
 
[New Latin, from Greek thalassa sea + -aemia, from it being esp prevalent round the eastern Mediterranean Sea]

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American Heritage
Medical Dictionary

thalassemia thal·as·se·mi·a (thāl'ə-sē'mē-ə)
n.
Any of a group of inherited forms of anemia occurring chiefly among people of Mediterranean descent, caused by faulty synthesis of part of the hemoglobin molecule.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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Science Dictionary
thalassemia   (thāl'ə-sē'mē-ə)  Pronunciation Key 
Any of a group of inherited forms of anemia occurring chiefly among people of Mediterranean descent, caused by faulty synthesis of part of the hemoglobin molecule
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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Encyclopedia Britannica
Encyclopedia

thalassemia

group of blood disorders characterized by a deficiency of hemoglobin, the blood protein that transports oxygen to the tissues. Hemoglobin is composed of a porphyrin compound (heme) and globin. Thalassemia is caused by genetically determined abnormalities in the synthesis of one or more of the polypeptide chains of globin. The various forms of the disorder are distinguished by different combinations of three variables: the particular polypeptide chain or chains that are affected; whether the affected chains are synthesized in sharply reduced quantities or not synthesized at all; and whether the disorder is inherited from one parent (heterozygous) or from both parents (homozygous)

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Encyclopedia Britannica, 2008. Encyclopedia Britannica Online.
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