thalassemia major

Medical Dictionary

thalassemia major thalassemia ma·jor (mā'jər)
A usually fatal form of thalassemia appearing in infancy or childhood in which normal hemoglobin is absent, characterized by severe anemia, enlargement of the heart, liver, and spleen, and skeletal deformation. Also called Cooley's anemia.

The American Heritage® Stedman's Medical Dictionary
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