[tim-buhk-too, tim-buhk-too]
a town in central Mali, W Africa, near the Niger River. French Tombouctou.
any faraway place.
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World English Dictionary
Timbuktu (ˌtɪmbʌkˈtuː)
1.  French name: Tombouctou a town in central Mali, on the River Niger: terminus of a trans-Saharan caravan route; a great Muslim centre (14th--16th centuries). Pop: 31 973 (1998)
2.  any distant or outlandish place: from here to Timbuktu

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin & History

city on the southern edge of the Sahara desert, older spelling Timbuctoo, used allusively in Eng. for "most distant place imaginable" from at least 1863.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Cultural Dictionary
Timbuktu [(tim-buk-tooh)]

A remote town in western Africa. Figuratively, it is a faraway and unknown place.

Timbuktu [(tim-buk-tooh)]

City in central Mali, in western Africa, near the Niger River.

Note: By the fourteenth century, it was famous for its gold trade.
The American Heritage® New Dictionary of Cultural Literacy, Third Edition
Copyright © 2005 by Houghton Mifflin Company.
Published by Houghton Mifflin Company. All rights reserved.
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