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c.1500, ultimately imitative, also found in Middle Low German and Low German tuten "blow a horn." Related: Tooted; tooting. The noun is recorded from 1640s. Meaning "cocaine" is attested by 1977. Tooting as a strong affirmative (e.g. you're damned tootin') is attested from 1932, American English. Toots as a slang familiar form of address to a woman or girl is recorded from 1936, American English.
The cartoons, esp the regular syndicated series: And Garfield now ranks at the top in 'toonville (1990s+)