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[trahy-sahy-klik, -sik-lik] /traɪˈsaɪ klɪk, -ˈsɪk lɪk/
pertaining to or embodying three cycles.
Also called tricyclic antidepressant. Pharmacology. any of a group of pharmacologically active substances, as imipramine, that share a common three-ring structure, used to treat depression and cocaine abuse.
Origin of tricyclic
1890-95; tri- + cyclic Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2015.
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British Dictionary definitions for tricyclic antidepressant


(of a chemical compound) containing three rings in the molecular structure
an antidepressant drug having a tricyclic molecular structure
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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tricyclic antidepressant in Medicine

tricyclic antidepressant tri·cy·clic antidepressant (trī-sī'klĭk, -sĭk'lĭk)
Any of a class of antidepressants, such as amitriptyline, that are structurally related to the phenothiazine antipsychotics.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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tricyclic antidepressant in Science
  (trī-sī'klĭk, -sĭk'lĭk)   
  1. Relating to a chemical compound having three closed rings. Anthracene is a tricyclic hydrocarbon.

  2. Relating to a class of drugs used to treat depression and having a tricyclic chemical structure consisting of two benzene rings fused to opposite sides of a seven-member ring. The seven-member ring consists of six carbon atoms and one nitrogen atom. Tricyclic antidepressants enhance the activity of monoamine neurotransmitters in the brain by inhibiting their reuptake by the cells that secrete them.

  3. Composed of or arranged in three distinct whorls, as the petals of a flower.

The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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