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Denotation vs. Connotation

trisomy 21

noun

Down syndrome

or Down's syndrome

noun, Pathology
1.
a genetic disorder, associated with the presence of an extra chromosome 21, characterized by mild to severe mental impairment, weak muscle tone, shorter stature, and a flattened facial profile.
Also called trisomy 21.
See also trisomy.
Origin of Down syndrome
1960-1965
1960-65; after John L. H. Down (1828-96), British physician
Usage note
Down syndrome (or Down's syndrome) has replaced earlier terms, such as mongolism to refer to the disease and Mongoloid or Mongol to refer to the affected person, all of which are now considered offensive.
Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2015.
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trisomy 21 in Medicine

trisomy 21 n.
See Down syndrome.

Down syndrome (doun) or Down's syndrome (dounz)
n.
A congenital disorder, caused by the presence of an extra 21st chromosome, in which the affected person has mild to moderate mental retardation, short stature, and a flattened facial profile. Also called trisomy 21, trisomy 21 syndrome.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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trisomy 21 in Science
trisomy 21  
See Down syndrome.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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