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1849, probably via South African Dutch, from a Bantu language (cf. Setswana tsetse. Luyia tsiisi "flies").
tsetse fly tset·se fly or tzet·ze fly (tsět'sē, tsē'tsē)
Any of several two-winged bloodsucking African flies of the genus Glossina, often carrying and transmitting pathogenic trypanosomes to humans and livestock.