verb (used with object)
to pinch and pull with a jerk and twist: to tweak someone's ear; to tweak someone's nose.
to pull or pinch the nose of, especially gently: He tweaked the baby on greeting.
to make a minor adjustment to: to tweak a computer program.
an act or instance of tweaking; a sharp, twisting pull or jerk.

1595–1605; akin to twitch Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
tweak (twiːk)
1.  to twist, jerk, or pinch with a sharp or sudden movement: to tweak someone's nose
2.  slang motor racing to tune (a car or engine) for peak performance
3.  informal to make a minor alteration
4.  an instance of tweaking
5.  informal a minor alteration
[Old English twiccian; related to Old High German zwecchōn; see twitch]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

probably from O.E. twiccian "to pluck," of obscure origin; perhaps related to twitch. Meaning "to make fine adjustments" is attested from 1966.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
We've tweaked procedures to make the process even smoother and more efficient.
When a home hits a bridge or a guardrail or gets tweaked during spotting,
  damage usually occurs.
But if the sound he wanted wasn't readily available through his instruments, he
  tweaked the wires himself.
Operators tweaked computerized marching and hazard-avoidance routines to speed
  the rover across the rocky flat.
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