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two strikes against

Strong factors opposing, as in There are two strikes against her possibility of a promotion. This term comes from baseball, where a batter is allowed three strikes at a fairly pitched ball before being called out; thus, a batter with two strikes has but one more chance to hit a fair ball. The figurative use dates from the early 1900s.
The American Heritage® Idioms Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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