adjective Slang.
tense, nervous, or jittery.
annoyed or angry.
stiffly conventional in manner or attitudes.

1960–65, Americanism; up (perhaps as intensifier) + tight

uptightness, noun
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World English Dictionary
uptight (ʌpˈtaɪt)
1.  displaying tense repressed nervousness, irritability, or anger
2.  unable to give expression to one's feelings, personality, etc

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

Slang sense of "tense" is from 1934; that of "straight-laced" first recorded 1969. It was used in a sense of "excellent" in jazz slang c.1962.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
If you're frantic and uptight, they can make things easier.
Everyone gets so uptight, but you might as well enjoy it when you're there.
It is often perceived as uptight and reactionary, mainly because its function
  is to uphold existing law.
The other reps are so uptight and tense they don't even talk to one another.
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