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vicissitude

[vi-sis-i-tood, -tyood] /vɪˈsɪs ɪˌtud, -ˌtyud/
noun
1.
a change or variation occurring in the course of something.
2.
interchange or alternation, as of states or things.
3.
vicissitudes, successive, alternating, or changing phases or conditions, as of life or fortune; ups and downs:
They remained friends through the vicissitudes of 40 years.
4.
regular change or succession of one state or thing to another.
5.
change; mutation; mutability.
Origin
1560-1570
1560-70; < Latin vicissitūdō, equivalent to viciss(im) in turn (perhaps by syncope < *vice-cessim; vice in the place of (see vice3) + cessim giving way, adv. derivative of cēdere to go, proceed) + -i- -i- -tūdō -tude
Related forms
vicissitudinous, adjective
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Based on the Random House Dictionary, © Random House, Inc. 2014.
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British Dictionary definitions for vicissitudinous

vicissitude

/vɪˈsɪsɪˌtjuːd/
noun
1.
variation or mutability in nature or life, esp successive alternation from one condition or thing to another
2.
a variation in circumstance, fortune, character, etc
Derived Forms
vicissitudinary, vicissitudinous, adjective
Word Origin
C16: from Latin vicissitūdō, from vicis change, alternation
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
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Word Origin and History for vicissitudinous

vicissitude

n.

1560s, from Middle French vicissitude (14c.), from Latin vicissitudinem (nominative vicissitudo) "change," from vicissim "changeably, in turn," from vicis "a turn, change" (see vicarious). Related: Vicissitudes.

Online Etymology Dictionary, © 2010 Douglas Harper
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