What is happening? what is the matter, question, problem, etc? (1881+)
The Dictionary of American Slang, Fourth Edition by Barbara Ann Kipfer, PhD. and Robert L. Chapman, Ph.D. Copyright (C) 2007 by HarperCollins Publishers. Cite This Source
Idioms and Phrases with what's with
what's up with;
what gives with. What is going on with; tell me about or explain it. For example, What's with all the food they're giving away? or What's up with Lee these days? or What gives with Jack? Why is he so glum? This idiom is also sometimes used as a substitute for how are you or what's wrong, as in Hi, Pam, what's with you? or What gives with you—why are you yelling?
[ ; c. 1940