Defeated; also, near death. For example, The home team knew it was all up when their star quarterback was injured, or The party lost their way over a week ago and in this subzero weather I'm sure it's all up with them. This idiom uses up in the sense of "finished." [Early 1700s] Also see all over, def. 4.
Dictionary.com presents 366 FAQs, incorporating some of the frequently asked questions from the past with newer queries.