point of no return

noun
1.
Aviation. the point in a flight at which an aircraft will lack sufficient fuel to return to its starting point.
2.
the critical point in an undertaking, decision-making process, etc., where one has committed oneself irrevocably to a course of action or policy.

Origin:
1940–45

Dictionary.com Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2013.
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Collins
World English Dictionary
point of no return
 
n
1.  a point at which an irreversible commitment must be made to an action, progression, etc
2.  a point in a journey at which, if one continues, supplies will be insufficient for a return to the starting place

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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00:10
Point of no return is always a great word to know.
So is interrobang. Does it mean:
a calculus or concretion found in the stomach or intestines of certain animals, esp. ruminants, formerly reputed to be an effective remedy for poison.
a printed punctuation mark (‽), available only in some typefaces, designed to combine the question mark (?) and the exclamation point (!), indicating a mixture of query and interjection, as after a rhetorical question.
American Heritage
Idioms & Phrases

point of no return

The place in a course of action beyond which reversal is not possible. For example, Once the contract is signed, we've reached the point of no return. This expression comes from aviation, where it signifies the point where an aircraft does not have enough fuel to return to the starting point. [c. 1940]

The American Heritage® Dictionary of Idioms by Christine Ammer.
Copyright © 1997. Published by Houghton Mifflin.
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Example sentences
We shall not sit and pray for nothing bad will happen when so many info shows
  it is at the tipping point of no return already.
It is the point of no return for many cancer patients.
At the risk of sounding alarmist, this might a point of no return.
We were able to take the process far enough to the point of no return, so that
  no one could turn back the clock.
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