Also, run up against or run into. Encounter something, especially a difficulty, unexpectedly. For example, We didn't know we'd run up against so much opposition, or He ran into trouble with his taxes. [Late 1300s]
Work against, as in Public sentiment ran against her. [Late 1300s]
Oppose for elective office, as in Susan decided to run against a very popular incumbent. This usage is a figurative application of running in a footrace. [First half of 1800s]
Dictionary.com presents 366 FAQs, incorporating some of the frequently asked questions from the past with newer queries.