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1-19 of 19 possibilities

attack intended to ruin someone's reputation assassination , blackwash , character assassination
ruin, great cataclysm , debacle
state of extreme (usually irremediable) ruin and misfortune catastrophe , disaster
breakdown and ruin debacle
ruin and impoverishment destitution
ruin or annihilate destroy
death or ruin doom
sudden ruin or decline downfall
ruin or doom downfall , undoing
allow to come to ruin neglect
ruin and prevent use obliterate
ruin property ravage , vandalize , wreck
save from ruin salvage
destroy or ruin scuttle
ruin a plan scuttle
ruin or impair spoil , vitiate
causing or attempting to cause the downfall or ruin of something subversive
bring to ruin undo
something or someone that has suffered ruin or dilapidation wreck
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