most cachectical

Science Dictionary
cachexia   (kə-kěk'sē-ə)  Pronunciation Key 
Severe weight loss, anorexia, and general debility that occur as a result of chronic disease. Cachetic patients exhibit signs of malnutrition, including muscle wasting.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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