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hemophilia

[ hee-muh-fil-ee-uh, -feel-yuh, hem-uh- ]

noun

  1. any of several X-linked genetic disorders, symptomatic chiefly in males, in which excessive bleeding occurs owing to the absence or abnormality of a clotting factor in the blood.


hemophilia

/ hē′mə-fĭlē-ə /

  1. Any of several hereditary coagulation disorders, seen almost exclusively in males, in which the blood fails to clot normally because of a deficiency or an abnormality of one of the clotting factors .


hemophilia

  1. A hereditary disease caused by a deficiency of a substance in the blood that aids in clotting. Hemophiliacs can bleed to death even from small cuts and bruises, because their blood has largely lost the ability to clot.


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Notes

Queen Victoria of Britain , whose descendants have been kings and queens of several countries in Europe , carried the gene for hemophilia, which has turned up repeatedly in royal families since her lifetime. Her great-grandson, the heir to the throne of Russia , suffered from the disease, and his parents fell under the influence of the monk Grigori Rasputin in hopes of a miraculous cure. The resulting chaos in the government of Russia helped bring on the Russian Revolution and the establishment of the Soviet Union .

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Word History and Origins

Origin of hemophilia1

From New Latin, dating back to 1850–55; hemo-, -philia

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Example Sentences

Producing the clotting factors missing in hemophilia patients is another possible application.

In late 2021, there were 46 gene therapies in the final, phase 3 stage of clinical trials, including High’s therapy for hemophilia, an early version of which was first tested in humans 20 years ago.

Moderate hemophilia, with levels 1 to 5 percent of the usual amount, can also include bleeding that occurs spontaneously, without a clear cause.

A gene-based therapy is potentially a step closer to becoming a one-time treatment for men with hemophilia.

Advances in gene therapy technology are making it possible to treat genetic diseases like hemophilia.

Benzene causes cancer, thins the blood to cause symptoms resembling hemophilia, and damages fetuses exposed to it.

Coagulation is notably delayed in hemophilia and icterus and after administration of citric acid.

Hemophilia is a peculiar disease, consisting in frequent and often uncontrollable hemorrhages.

An even more striking manifestation of a physical anomaly, as a family trait, is the condition known as hemophilia.

In 1539 Benedictus noted the occurrence of hemophilia or bleeders' disease.

In hemophilia, uncontrollable bleeding may occur from trifling injuries.

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hemophilehemophiliac