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-cule1

1.
variant of -cle1 :
animalcule; molecule; reticule.
Origin
(< F) < Latin -culus, -cula, -culum; see -cle1

-cule2

1.
variant of -cle2 :
ridicule.
Origin
(< F) < Latin -culum, -cula; see -cle2
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Based on the Random House Dictionary, © Random House, Inc. 2014.
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British Dictionary definitions for -cule

-cule

suffix
1.
indicating smallness: animalcule
Word Origin
from Latin -culus, diminutive suffix; compare -cle
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
© William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009, 2012
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Word Origin and History for -cule

word-forming element used to make diminutives, from French -cule or directly from Latin -culus (masc.), -cula (fem.), -culum (neuter).

Online Etymology Dictionary, © 2010 Douglas Harper
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