Down syndrome

Down syndrome

noun Pathology.
a genetic disorder, associated with the presence of an extra chromosome 21, characterized by mild to severe mental impairment, weak muscle tone, shorter stature, and a flattened facial profile.
Also, Down's syndrome.
Also called trisomy 21.
See trisomy.


Origin:
1960–65; after John L. H. Down (1828–96), British physician


Down syndrome (or Down's syndrome) has replaced earlier terms, such as mongolism to refer to the disease and Mongoloid or Mongol to refer to the affected person, all of which are now considered offensive.
Dictionary.com Unabridged

Down's syndrome

noun Pathology.
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Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
Down's syndrome or (US) Down syndrome
 
n
a.  pathol Former name: mongolism, Technical name: trisomy 21 a condition caused by the presence of an extra copy of chromosome 21 resulting in learning difficulties and physical differences, such as shorter stature
 b.  (as modifier): a Down's syndrome baby
 
usage  
 
Down syndrome or (US) Down syndrome
 
n
 
usage  

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Etymonline
Word Origin & History

Down's Syndrome
1961, from J.L.H. Down (1828-1896), English physician; chosen as a less racist name for the condition than earlier mongolism.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

Down syndrome (doun) or Down's syndrome (dounz)
n.
A congenital disorder, caused by the presence of an extra 21st chromosome, in which the affected person has mild to moderate mental retardation, short stature, and a flattened facial profile. Also called trisomy 21, trisomy 21 syndrome.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
Down syndrome (doun) or Down's Syndrome   (doun)  Pronunciation Key 
A congenital disorder caused by the presence of an extra 21st chromosome. People with Down syndrome have mild to moderate mental retardation, short stature, and a flattened facial profile. The syndrome is named after its discoverer, British physician John Langdon Haydon Down (1828-1896).
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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American Heritage
Cultural Dictionary

Down's syndrome definition


A congenital condition, caused by an abnormality in the chromosomes, marked by moderate to severe mental retardation and changes in certain physical features.

The American Heritage® New Dictionary of Cultural Literacy, Third Edition
Copyright © 2005 by Houghton Mifflin Company.
Published by Houghton Mifflin Company. All rights reserved.
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