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Graafian follicle Graaf·i·an follicle or graaf·i·an follicle (grä'fē-ən, grāf'ē-)
A mature ovarian follicle in which the oocyte attains its full size and the surrounding follicular cells are permeated by one or more fluid-filled cavities. Also called secondary follicle, vesicular ovarian follicle.