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methotrexate

[ meth-oh-trek-seyt ]

noun

, Pharmacology.
  1. a toxic folic acid analogue, C 2 0 H 2 2 N 8 O 5 , that inhibits cellular reproduction, used primarily in the treatment of psoriasis and certain cancers and as an immunosuppressive agent.

methotrexate

/ ˌmɛθəʊˈtrɛkseɪt; ˌmiːθəʊ- /

noun

  1. an antimetabolite drug used in the treatment of certain cancers. Formula: C 20 H 22 N 8 O 5

methotrexate

/ mĕth′ə-trĕk′sāt /

  1. A toxic drug that acts as a folic acid antagonist to interfere with cellular reproduction and is used in the treatment of psoriasis, certain cancers, and certain inflammatory diseases, such as rheumatoid arthritis. Chemical formula: C 20 H 22 N 8 O 5 .

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Word History and Origins

Origin of methotrexate1

1950–55; metho(xy)- + trexate, of unclear derivation

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