Mid·west (mĭd-wěst') A region of the north-central United States around the Great Lakes and the upper Mississippi Valley. It is generally considered to include Ohio, Indiana, Illinois, Michigan, Wisconsin, Minnesota, Iowa, Missouri, Kansas, and Nebraska. The area is known for its rich farmlands and highly industrialized centers. Mid·west'ern adj., Mid·west'ern·er n.
1926, in U.S. geographical sense, from earlier Midwestern (1889) in ref. to a group of states originally listed as W.Virginia, Kentucky, Tennessee, Missouri, Kansas, and Arkansas.