excruciating or acute distress, suffering, or pain: the anguish of grief.
verb (used with object)
to inflict with distress, suffering, or pain.
verb (used without object)
to suffer, feel, or exhibit anguish: to anguish over the loss of a loved one.

1175–1225; Middle English anguisse < Old French < Latin angustia tight place, equivalent to angust(us) narrow + -ia -ia; cf. anxious; akin to anger

1. agony, torment, torture. See pain.

1. delight, comfort, relief. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
anguish (ˈæŋɡwɪʃ)
1.  extreme pain or misery; mental or physical torture; agony
2.  to afflict or be afflicted with anguish
[C13: from Old French angoisse a strangling, from Latin angustia narrowness, from angustus narrow]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

early 13c., "acute bodily or mental suffering," from O.Fr. anguisse, angoisse "choking sensation, distress, anxiety, rage," from L. angustia "tightness, distress," from ang(u)ere "to throttle, torment" (see anger). The verb is attested from early 14c., intrans.; late 14c., trans.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
The film shows that freedom is fraught with anguish and pain.
Add to that pain the anguish of dozens of relatives and friends.
So great was the extremity of his pain and anguish, that he did not only sigh
  but roar.
The singer/songwriter suffered similar anguish during the wrenching process of
  writing his autobiography.
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