“Thirty minutes alone with a man is enough for him to annihilate you,” she remarks, knowingly.
Finally there was the atomic bomb (and the Cold War it created): machine threatened to annihilate all of mankind.
He then went on to compare us to Amalek, the Biblical nation that God commands the Jews to annihilate.
1520s, from an obsolete adjective meaning "reduced to nothing" (late 14c.), originally the past participle of a verb, anihil, from Old French annichiler (14c.), from Late Latin annihilare "to reduce to nothing," from Latin ad- "to" (see ad-) + nihil "nothing" (see nil). Related: Annihilated; annihilating.