an aerial bomb containing high explosives and weighing from four to eight tons, used as a large-scale demolition bomb.
a motion picture, novel, etc., especially one lavishly produced, that has or is expected to have wide popular appeal or financial success.
something or someone that is forcefully or overwhelmingly impressive, effective, or influential: The campaign was a blockbuster.
a real-estate speculator who practices blockbusting.

1940–45; block + buster Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
blockbuster (ˈblɒkˌbʌstə)
1.  a large bomb used to demolish extensive areas or strengthened targets
2.  a very successful, effective, or forceful person, thing, etc
3.  a lavish film, show, novel, etc, that proves to be an outstanding popular success

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

big bomb (4,000 pounds or larger, according to some sources), 1942, from block in the "built-up city square" sense. Entertainment sense is attested from 1957.
Online Etymology Dictionary, © 2010 Douglas Harper
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Example sentences
It could have been the premiere of a summer blockbuster.
The right gear-and tips from the pros-will make your next vacation video a
If replicated, that's a stunning finding, a potential blockbuster for patients.
Genomics will make possible the kind of customization that undermines the drug
  industry's blockbuster mentality.
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