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1570s, "one who produces or originates," agent noun from breed (v.). Meaning "one who breeds cattle" or some other animal is recorded from 1530s. Of nuclear reactors, from 1948. As a scornful homosexual term for "heterosexual person," attested from 1986.
A heterosexual person; straight: the scornful term ''breeders,'' used by some urban gays about heterosexual couples with children (1980s+ Homosexuals)