a combining form meaning “bad,” occurring in loanwords from Greek (cacodemon ); on this model, used in the formation of compound words (cacogenics ).
Also, especially before a vowel, cac-.

< Greek, combining form of kakós Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
combining form
bad, unpleasant, or incorrect: cacophony
[from Greek kakos bad]

Collins English Dictionary - Complete & Unabridged 10th Edition
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Word Origin & History

before vowels, cac-, prefix meaning "bad, ill, poor," from Gk. kako- a common prefix in Gk., from kakos "bad, evil," considered by etymologists to probably be connected with PIE *kakka- "to defecate" (see caca). E.g. cacography, the opposite of calligraphy.
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

caco- or cac-
Bad: cacogeusia.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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