"You canker blossom!" 3 Shakespearean Insults
1725, from French caramel "burnt sugar" (17c.), via Old Spanish caramel (modern caramelo), ultimately from Medieval Latin cannamellis, traditionally from Latin canna (see cane (n.)) + mellis, genitive of mel "honey" (see Melissa). But some give the Medieval Latin word an Arabic origin, or trace it to Latin calamus "reed, cane."