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cardinal sin

noun
1.
(theol) any of the seven deadly sins
2.
(informal) an unforgivable error or misjudgment: lack of impartiality is considered a cardinal sin in broadcasting circles
Collins English Dictionary - Complete & Unabridged 2012 Digital Edition
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Contemporary definitions for cardinal sin
noun

a principal or prime misdeed; a serious error in judgment

Examples

He committed the cardinal sin of journalism.

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