noun Physiology.
an endocrine secretion that depresses or inhibits physiological activity.

1910–15; < Greek chalôn, present participle of chalân to slacken, loosen; on the model of hormone Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
chalone (ˈkæləʊn)
any internal secretion that inhibits a physiological process or function
[C20: from Greek khalōn, from khalan to slacken]

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American Heritage
Medical Dictionary

chalone cha·lone (kā'lōn', kāl'ōn')

  1. A hormone that inhibits rather than stimulates.

  2. Any of several polypeptides produced by a tissue and causing the reversible inhibition of mitosis in cells of that tissue.

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