constant; habitual; inveterate: a chronic liar.
continuing a long time or recurring frequently: a chronic state of civil war.
having long had a disease, habit, weakness, or the like: a chronic invalid.
(of a disease) having long duration (opposed to acute ).
Slang. cronic.
Also, chronical.

1595–1605; < Latin chronicus < Greek chronikós, equivalent to chrón(os) time + -ikos -ic

chronically, adverb
chronicity [kro-nis-i-tee] , noun
nonchronic, adjective
nonchronical, adjective
nonchronically, adverb
subchronic, adjective
subchronical, adjective
subchronically, adverb
unchronic, adjective
unchronically, adverb

acute, chronic.

1. confirmed, hardened. Unabridged
Based on the Random House Dictionary, © Random House, Inc. 2014.
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World English Dictionary
chronic (ˈkrɒnɪk)
1.  continuing for a long time; constantly recurring
2.  Compare acute (of a disease) developing slowly, or of long duration
3.  inveterate; habitual: a chronic smoker
4.  informal
 a.  very bad: the play was chronic
 b.  very serious: he left her in a chronic condition
[C15: from Latin chronicus relating to time, from Greek khronikos, from khronos time]

Collins English Dictionary - Complete & Unabridged 10th Edition
2009 © William Collins Sons & Co. Ltd. 1979, 1986 © HarperCollins
Publishers 1998, 2000, 2003, 2005, 2006, 2007, 2009
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Word Origin & History

c.1600 (earlier form was chronical, 1520s), from O.Fr. chronique, from L. chronicus, from Gk. khronikos "of time," from khronos "time." Vague disapproving sense is from association with diseases (a connection found since c.1600).
Online Etymology Dictionary, © 2010 Douglas Harper
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American Heritage
Medical Dictionary

chronic chron·ic (krŏn'ĭk)
Of long duration. Used of a disease of slow progress and long continuance.

The American Heritage® Stedman's Medical Dictionary
Copyright © 2002, 2001, 1995 by Houghton Mifflin Company. Published by Houghton Mifflin Company.
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American Heritage
Science Dictionary
chronic   (krŏn'ĭk)  Pronunciation Key 
Relating to an illness or medical condition that is characterized by long duration or frequent recurrence. Diabetes and hypertension are chronic diseases. Compare acute.
The American Heritage® Science Dictionary
Copyright © 2002. Published by Houghton Mifflin. All rights reserved.
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Example sentences
Chronic or recurrent acute sinusitis can be a lifelong condition.
Discovering how bears prevent urine from entering the kidneys could help treat
  patients suffering from chronic kidney failure.
Chronic power outages and electrical fluctuations have been the norm.
Either way, shortening is linked to chronic disease risk and diminished
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