"You canker blossom!" 3 Shakespearean Insults
"sedative," 1876 as a noun, 1887 as an adjective; see depress + -ant.
depressant de·pres·sant (dĭ-prěs'ənt)adj. Tending to lower the rate of vital physiological activities. n. An agent, especially a drug, that decreases the rate of vital physiological activities.